Eif4a2

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August undefined, 2024

WebMar 30, 2024 · (A) eIF4A2 binds to the TIR of its targets to activate the translation initiation: eIF4A2 activates the translation initiation of H3.3 and Rps26 through Rps26-dependent … WebJun 14, 2024 · Abstract. Eukaryotic initiation factor 4A (eIF4A), the enzymatic core of the eIF4F complex essential for translation initiation, plays a key role in the oncogenic …

eIF4A2 drives repression of translation at initiation by

WebThe eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to … WebJul 1, 2000 · Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. takenoko second edition

DEVELOPMENTAL BIOLOGY Copyright © 2024 eIF4A2 targets …

WebBackground: EIF4A2, which belongs to the eukaryotic initiation factor 4A family, is a highly conserved gene for one of the protein-synthesis initiation factors involved in the binding of messenger RNA to the ribosome. The role of EIF4A2 in some cancers, eg, breast cancer and melanoma, has been studied. Webof eIF4A2 (15), can rescue the eIF4A2 KD effects on ESC proliferation, morphology, and the expression of differentiation and 2C transcripts (Fig. 1E, and fig. S1, P and Q). These results established the essential role of eIF4A2 in maintaining the pluripotency. However, over expression of eIF4A2 in ESCs (fig. S2A) had minimal effects on the WebDec 2, 2024 · eIF4A2 forms an endogenous complex with CNOT1. eIF4A1 and eIF4A2 have been reported to have non-redundant divergent roles in translation regulation [11, 38, … taken online subtitrat in romana

EIF4A2 Monoclonal Antibody (2D11E11) - Thermo Fisher Scientific

eIF4A - Wikipedia

WebEukaryotic translation initiation factor 4A2 (eIF4A2) is necessary for efficient HIV-1 replication in human lymphoid cell line. eIF4A2 depletion reduces the efficiency of viral … WebAnti-eIF4A2 antibody (ab31218) at 1 µg/ml + Jurkat whole cell lysate at 20 µg Secondary IR Dye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution Performed under reducing conditions. Predicted band … taken one direction testoWebJun 15, 2016 · We show here that eIF4A2 is modified by SUMO, with sumoylation occurring on a single residue (K226). We demonstrate that sumoylation of eIF4A2 is modestly increased in response to arsenite and ionising radiation, but decreases in response to heat shock or hippuristanol. take no notice of crossword

"WebJan 5, 2024 · Eukaryotic initiation factor-4A2 (EIF4A2) is an ATP-dependent RNA helicase and a member of the DEAD-box protein family that recognizes the 5' cap structure of … " - Eif4a2

Eif4a2

Inhibition of translation initiation factor eIF4a inactivates …

WebJun 1, 2024 · These results suggest that eIF4A2 is a host factor required for HIV-1 infection. The phenotype of the different shRNAs further suggests that the inhibition of NL4-3luc-RC infection may not be an off-target effect. 3.2. Depletion of eIF4A2 reduces the efficiency of HIV-1 cDNA synthesis. WebTarget Information. eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a …

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WebDec 8, 2024 · EIF4A2. eukaryotic translation initiation factor 4A2. Gene ID: 1974, updated on 6-Nov-2024. Gene type: protein coding. Also known as: DDX2B; EIF4A; EIF4F; BM … WebMay 3, 2016 · The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). Upon AIEC infection, autophagy is induced in host …

WebApr 1, 2024 · The EIF4A2 gene is located approximately 1 MB away from BCL6 on chromosome 3q27 in a tail-to-tail orientation ( Fig. 2 ), and this rearrangement is reportedly produced by a paracentric inversion which is cryptic to FISH analysis [39], as was also seen in the current report.

WebMar 21, 2024 · EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Fragile X-Associated Tremor/Ataxia Syndrome and Spinocerebellar Ataxia … WebTarget Information eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre …

WebDec 25, 2024 · We identified eIF4A2 and defined its mechanistic action through Rps26-independent and -dependent ribosomes in translation initiation activation of mRNAs encoding pluripotency factors and the histone variant H3.3 with demonstrated roles in maintaining stem cell pluripotency. eIF4A2 also mediates translation initiation activation …

WebeIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency. Translational control has emerged as a fundamental regulatory … twitch anime transitions freeWebApr 1, 2024 · EIF4A2 may be associated with TGEV replication in porcine intestinal cells. Abstract Transmissible gastroenteritis coronavirus (TGEV) is enteropathogenic coronavirus that causes diarrhea in pigs, and is associated with … taken on side ac of a triangle abcWebeIF4A2 is a TIF, but its depletion did not alter global translation rates in ESCs (Fig. 2A). The lack of a global effect on translation upon eIF4A2 loss was also reported in … take non degree accounting courses mnWebThe eukaryotic initiation factor-4A ( eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. [1] [2] Background [ edit] take no notice of crossword clueWebEif4a2 eukaryotic translation initiation factor 4A2 [ (house mouse)] Gene ID: 13682, updated on 8-Dec-2024 Summary Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. twitch anketWebIn molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression … twitch anket açmaWebFeb 7, 2024 · The most prominent examples are those of SNORA63/EIF4A2, SNORA63E/LINC00888, SNORD66/EIF4G1. These couples undergo CNA in a significant portion of patients in HNSC, KIRC, SKCM, OV, and GBM; in all these tumor types, these 3 couples are altered in similar percentages of patients, ranging from 7–8% in OV cancer, … taken on this call before reaching tout